Comparison of immunophenotypes of primary breast carcinomas and multiple corresponding distant metastases: an autopsy study of 25 patients

Székely, Borbála and Nagy, Zsófia and Farago, Zsofia and Kiss, Orsolya and Lotz, Gábor and Kovács, Kristóf Attila and Madaras, Lilla and Udvarhelyi, Nóra and Dank, Magdolna and Szentmártoni, Gyöngyvér and Baranyai, Zsolt and Harsányi, László and Tőkés, Anna-Mária and Tímár, József and Szász, Attila Marcell and Kulka, Janina (2017) Comparison of immunophenotypes of primary breast carcinomas and multiple corresponding distant metastases: an autopsy study of 25 patients. Clinical & Experimental Metastasis, 34 (1). pp. 103-113. ISSN 0262-0898 (Print) 1573-7276 (Online)

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Abstract

Phenotypical change in metastatic breast carcinoma has widely been accepted as an inherent biological feature rather than technical fault. We analyzed the immunohistochemical phenotype and histopathological features of 25 primary breast carcinomas and 90 corresponding distant metastases in 23 organs retrospectively. Histological slides were reviewed for prognostic and predictive factors. Overall, metastases were more similar to each other and often differed from the primary tumor. We created a 3-step grouping system based on the localization of metastases. Regions: tumors metastasizing to the abdominal region were likely to lose ER (p = 0.002); we detected loss of PR in metastases to the thorax (p = 0.039) and abdomen (p < 0.001). Organ systems: loss of ER and PR was observed in metastases to the gastrointestinal system (p = 0.026 and p = 0.001, respectively), in the respiratory system only the loss of PR was significant (p = 0.05). Individual organs: the primaries were likely to lose the hormone receptors in liver metastases (ER p = 0.026; PR p = 0.004). In lung metastases only loss of PR was apparent (p = 0.049). We did not observe significant change in HER2 status, regarding Ki67 change occurred only in bone metastases compared to the primary (p = 0.048). 7/25 patients’ distant metastases had heterogeneous immunoprofiles. The later the metastasis was discovered the more likely it had a differing IHC profile compared to the primary tumor, patients who had longer OS had a higher chance to develop a discordant metastasis. Immunoprofile of metastases may differ from primary breast cancer and from each other, probably resulting in different response to therapy.

Item Type:	Article
Subjects:	R Medicine / orvostudomány > R1 Medicine (General) / orvostudomány általában R Medicine / orvostudomány > RB Pathology / patológia, kórtan
Depositing User:	Dr. Attila Marcell Szasz
Date Deposited:	28 Sep 2017 13:06
Last Modified:	28 Sep 2017 13:08
URI:	http://real.mtak.hu/id/eprint/64113

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