Kezdeti tapasztalataink a petefészekszövet-fagyasztás bevezetésével

Fancsovits, Péter and Urbancsek, János and Fónyad, László and Sebestyén, Anna and Csorba, Gézáné and Lehner, Ádám and Kaszás, Zita and Rigó jr., János and Bokor, Attila (2016) Kezdeti tapasztalataink a petefészekszövet-fagyasztás bevezetésével. Orvosi Hetilap. pp. 1947-1954. ISSN 0030-6002

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Abstract

INTRODUCTION: The oncological treatment may damage ovarian function. To prevent this, it is possible to cryopreserve the ovarian tissue, and to keep the samples for long-term storage. The frozen-thawed tissue could be retransplanted after chemo- or radiotherapy. AIM: The aim of our study was to examine the effect of cryopreservation on the viability of ovarian tissue. METHOD: We analyzed the survival of frozen-thawed donated ovarian tissues. The quality of the follicles and hormone production in fresh and frozen-thawed samples were compared. RESULTS: Histological analysis showed that the number of viable follicles was reduced by 23% in the frozen-thawed samples. However, viable follicles still presented in post thawing ovarian tissues. Maximal estradiol production in frozen-thawed tissues was 908 pg/ml and hormone production was similar to the control tissues. The maximal progesterone production was 1.95 ng/ml post thawing, but these values were lower than the progesterone production of fresh tissues. CONCLUSIONS: The method of ovarian cryopreservation used in our laboratory was able preserve the viability of follicles in frozen-thawed ovarian tissues. Orv. Hetil., 2016, 157(49), 1947-1954.

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