REAL

Altered open field behaviour in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement

Hebőkné Lukács, Anita and Szabó, Andrea and Papp, András and Vezér, Tünde (2009) Altered open field behaviour in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement. ACTA BIOLOGICA HUNGARICA, 60. pp. 359-367. ISSN 0236-5383

[img] Text
1294317 Lukács.pdf
Restricted to Registered users only

Download (1MB) | Request a copy

Abstract

3-nitropropionic acid (3-NP), a substance used for modelling Huntington’s disease, was given to male Wistar rats once in 20 mg/kg b.w. dose, and the resulting behavioural alterations in spontaneous locomotor activity were measured after 30 minutes. To detect the involvement of neurotransmitter systems in this immediate effect, the NMDA antagonist MK-801 (0.8 mg/kg); as well as an agonist, quinpirole (QP, 5 mg/kg) and an antagonist, sulpiride (SP, 80 mg/kg) of the dopamine D2 receptors, were given before 3-NP to separate groups of rats. Controls were given saline. All substances were injected ip. 3-NP decreased the rats’ locomotor, especially vertical, activity, whereas local activity was increased. Based on the further changes of 3-NP effects in the combination groups it could be concluded that dopaminergic rather than glutamatergic mechanisms were possibly involved in the acute behavioural effect of 3-NP.

Item Type: Article
Subjects: R Medicine / orvostudomány > RC Internal medicine / belgyógyászat > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry / idegkórtan, neurológia, pszichiátria
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 05 Sep 2013 15:06
Last Modified: 05 Sep 2013 15:06
URI: http://real.mtak.hu/id/eprint/6460

Actions (login required)

Edit Item Edit Item