Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies

Varbiro, Sz. and Biro, A. and Cervenak, J. and Cervenak, L. and Singh, M. and Banhidy, F. and Sebestyen, A. and Füst, G. and Prohászka, Z. (2010) Human anti-60 kD heat shock protein autoantibodies are characterized by basic features of natural autoantibodies. Acta Physiologica Hungarica, 97 (1). pp. 1-10. ISSN 0231-424X

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Abstract

Anti-human Hsp60 autoantibodies — known risk factor of atherosclerosis — were investigated in a mouse model and in samples of healthy subjects: polyreactivity, presence in cord blood samples of healthy newborns and life-long stability were tested. In IgM hybridoma panel from mouse spleens, polyreactivity of anti-Hsp60 autoantibodies was studied. In healthy pregnant women, umbilical vein and maternal blood samples were collected after childbirth, anti-Hsp-60 and -65 IgM and IgG levels were measured. Life-long stability of anti-Hsp-60 levels was studied on healthy patients during 5 years. ELISA was used in all studies. Polyreactivity of IgM clones of newborn mice and lifelong stability of these autoantibodies in healthy adults were established. IgM anti-Hsp60 autoantibodies in cord blood of healthy human infants were present, however, there was no correlation between maternal and cord blood IgM anti-Hsp60 concentrations. It is proposed that presence of anti-Hsp60 autoantibodies — as part of the natural autoantibody repertoire — may be an inherited trait. Level of anti-Hsp60 autoantibodies may be an independent, innate risk factor of atherosclerosis for the adulthood.

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