Opposite effect of Cu(II) and Se(IV) ions on the antibacterial-toxic action of mycotoxins

Móricz, Ágnes and Ott, P. and Szilágyi, M. and Otta, Klára and Tyihák, E. (2007) Opposite effect of Cu(II) and Se(IV) ions on the antibacterial-toxic action of mycotoxins. Acta Biologica Hungarica, 58 (3). pp. 301-310. ISSN 0236-5383

Text abiol.58.2007.3.6.pdf Restricted to Repository staff only until 30 September 2027. Download (1MB)

Abstract

The effect of Se(IV) and Cu(II) ions on the antibacterial activity of aflatoxins and ochratoxin A (myco- toxins) was studied in BioArena as a complex bioautographic system. In the presence of 0.23 and 0.46 mg/100 mL Se(IV) the inhibition zones of mycotoxins were decreased, however, lower concentration (0.046 mg/100 mL) increased the antibacterial effect of aflatoxin B1. Cu(II) (1.53 mg/100 mL) enhanced the toxicity of mycotoxins. The results supported the possible role of formaldehyde and its reaction prod- ucts (e.g. 1 O 2 , O 3 ) in the antibacterial-toxic action of mycotoxins. Cu(II) can probably generate and mobilise the formaldehyde molecules and so it could increase the toxicity with its potential reaction prod- ucts. It is possible that the enzymatic or spontaneous methylation of Se(IV) takes place through formalde- hyde, which may cause partial formaldehyde depletion in the system. The enhanced antibacterial effect at low concentration Se(IV) is overlapping with the often experienced prooxidant effect in cases of nat- ural antioxidants.

Actions (login required)

Edit Item