Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips

Unal, Meral and Palavan-Unsal, Narcin and Tufekci, M. (2008) Effects of polyamines and polyamine biosynthetic inhibitors on mitotic activity of Allium cepa root tips. Acta Biologica Hungarica, 59 (1). pp. 93-102. ISSN 0236-5383

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Abstract

The genotoxic and cytotoxic effects of exogenous polyamines (PAs), putrescine (Put), spermidine (Spd), spermine (Spm) and PA biosynthetic inhibitors, α-difluoromethylornithine (DFMO), cyclohexilamine (CHA), methylglioxal bis-(guanylhydrazone) (MGBG) were investigated in the root meristems of Allium cepa L. The reduction of mitotic index and the induction of chromosomal aberrations such as bridges, stickiness, c-mitotic anaphases, micronuclei, endoredupliction by PAs and PA biosynthetic inhibitors were observed and these were used as evidence of genotoxicity and cytotoxicity.

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