Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats

Chater, S. and Douki, T. and Favier, A. and Sakly, M. and Abdelmelek, H. (2009) Changes in antioxidant status and biochemical parameters after orally cadmium administration in females rats. Acta Biologica Hungarica, 60 (1). pp. 79-88. ISSN 0236-5383

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Abstract

The research was conducted to investigate the toxic effects of cadmium chloride (CdCl 2 ), administered during gestation period on female Wistar rats. Pregnant rats received CdCl 2 (20 mg/l, orally) from Day 6 to Day 19 of pregnancy. Results showed that Cd treatment induced a decrease in body weight gain. The relative liver weight increased significantly, with a marked decrease of glycogen and total lipids content. The administration of Cd induced hepatotoxicity as indicated by elevations in plasma alanine amino- transferase (ALT), aspartate aminotransferase and lactate dehydrogenase (LDH) activities ( p < 0.05). Treatment with CdCl 2 caused a significant ( p < 0.05) increase in glucose. A significant increase was observed in the level of MDA and 8-oxodGuo tissues in the cadmium-exposed group compared to the control group ( p < 0.05). Results showed that cadmium given to dams led to an oxidative stress and DNA damage in tissues of pregnant rats

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