Delayed action of serotonin in molluscan development

Voronezhskaya, Elena and Khabarova, Marina and Nezlin, L. and Ivashkin, E. (2012) Delayed action of serotonin in molluscan development. Acta Biologica Hungarica, 63 (Supple). pp. 210-216. ISSN 0236-5383

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Abstract

Serotonin (5-HT) is known to induce a wide range of short-term and long-term (or delayed) effects. In the present paper we demonstrated that short time-window application of the 5-HT precursor 5-hydroxytryptophan during early cleavage stages results in both irreversible morphological malformation (exogastrulation) and distinct changes in behavior of young animals of the freshwater snail, Lymnaea stagnalis (Mollusca: Gastropoda). Pharmacological and immunocytochemical analysis confirmed that both the increase of intracellular 5-HT level within the cleaved blastomers and activation of membrane 5-HT₂-like type receptors are required for the appearence of these phenomena.

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