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Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues

Adamska-Bartlomiejczyk, Anna and Borics, Attila and Tömböly, Csaba and Dvorácskó, Szabolcs and Lisowski, Marek (2017) Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues. JOURNAL OF PEPTIDE SCIENCE, 23 (12). pp. 864-870. ISSN 1075-2617

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Abstract

Three novel morphiceptin analogs, in which Pro in position 2 and/or 4 was replaced by cis-4-aminoproline connected with the preceding amino acid through the primary amino group, were synthesized. The opioid receptor affinities, functional assay results, enzymatic degradation studies and experimental and in silico structural analysis of such analogs are presented. Copyright (c) 2017 European Peptide Society and John Wiley & Sons, Ltd.

Item Type: Article
Uncontrolled Keywords: SCAFFOLD; PROTEINS; PEPTIDES; SIMULATION; ACID; PROLINE; FORCE-FIELD; LINEAR ENDOMORPHIN-2 ANALOGS; receptor docking; CIRCULAR DICHROISM; ezymatic degradation; binding assays; PEPTIDE SYNTHESIS
Subjects: Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3011 Biochemistry / biokémia
Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia > QH3015 Molecular biology / molekuláris biológia
SWORD Depositor: MTMT SWORD
Depositing User: MTMT SWORD
Date Deposited: 23 Jan 2018 11:00
Last Modified: 23 Jan 2018 11:00
URI: http://real.mtak.hu/id/eprint/73139

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