High-yielding synthesis of N-triazolyl carboxamides via palladium-catalysed aminocarbonylation

Gergely, Máté and Boros, Borbála and Kollár, László (2017) High-yielding synthesis of N-triazolyl carboxamides via palladium-catalysed aminocarbonylation. TETRAHEDRON, 73. pp. 6736-6741. ISSN 0040-4020

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Abstract

Aminocarbonylation of alkenyl and aryl iodides in the presence of 4-amino-4H-1,2,4-triazole as Nnucleophile was carried out in the presence of palladium catalysts. Both types of substrates have shown high chemoselectivity toward carboxamides, i.e. practically no double carbon monoxide insertion resulting in 2-ketocarboxamides took place. The results have been rationalised on the basis of mechanistic aspects of aminocarbonylation.

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