Könye, Rita and Tóth, G. and Sólyomváry, Anna and Mervai, Zsolt and Zürn, M. and Perlné Molnár, Ibolya and Béni, Szabolcs and Boldizsár, Imre (2018) Chemodiversity of Cirsium fruits: Antiproliferative lignans, neolignans and sesquineolignans as chemotaxonomic markers. FITOTERAPIA, 127. pp. 413-429. ISSN 0367-326X
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Abstract
While analyzing the fruit composition of nine European Cirsium species representing three sections (i.e., Cephalonoplos, Chamaeleon and Eriolepis), four lignans, three neolignans and three sesquineolignans were determined and used as chemotaxonomic markers. Among them, desmethyl balanophonin and desmethyl picrasmalignan were determined for the first time in the plant kingdom, as the main metabolites of the Chamaeleon section. Prebalanophonin and prepicrasmalignan, identified so far exclusively in C. eriophorum, were also confirmed in C. boujartii and C. vulgare, highlighting the chemotaxonomic significance of these compounds in the Eriolepis section. The antiproliferative assay of the compounds isolated from their optimum sources, confirmed a dose-dependent inhibitory effect of the structures bearing the 4′,7-epoxy moiety (balanophonin, picrasmalignan, desmethyl balanophonin, desmethyl picrasmalignan) against SW480 colon cancer cells, while those bearing the 4′,7-dihydroxy motif (prebalanophonin, prepicrasmalignan) were inactive. © 2018 Elsevier B.V.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QD Chemistry / kémia R Medicine / orvostudomány > RS Pharmacy and materia medica / gyógyszerészet, gyógyászati eszközök R Medicine / orvostudomány > RV Botanic, Thomsonian, and eclectic medicine / természetgyógyászat |
SWORD Depositor: | MTMT SWORD |
Depositing User: | MTMT SWORD |
Date Deposited: | 29 May 2018 14:22 |
Last Modified: | 29 May 2018 14:22 |
URI: | http://real.mtak.hu/id/eprint/80226 |
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