SOD-Like Activity of Copper(II) Containing Metallopeptides Branched By 2,3-Diaminopropionic Acid: What the N-Termini Elevate, the C-Terminus Ruins

Szyrwiel, Łukasz and Shimura, Mari and Setner, Bartosz and Szewczuk, Zbigniew and Malec, Katarzina and Malinka, Wiesław and Brasun, Justyna and Pap, József Sándor (2018) SOD-Like Activity of Copper(II) Containing Metallopeptides Branched By 2,3-Diaminopropionic Acid: What the N-Termini Elevate, the C-Terminus Ruins. International Journal of Peptide Research and Therapeutics. pp. 1-7. ISSN 1573-3904

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Abstract

Relations between structural modifiactions and SOD-like activity of four branched CuII-metallopeptides based on l-2,3-diaminopropionic acid are reported. The IC 50 values (McCord–Fridovich method) illustrate that enhanced SOD-like activity is warranted by exclusive N-terminal His localization that surmounts the driving force by the CuII/I formal potential.

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