A De Novo Synthetic Route to 1,2,3,4-Tetrahydroisoquinoline Derivatives

Abrahami, Renata Anita and Fustero, Santos and Fülöp, Ferenc and Kiss, Loránd (2018) A De Novo Synthetic Route to 1,2,3,4-Tetrahydroisoquinoline Derivatives. SYNLETT. pp. 2066-2070. ISSN 0936-5214

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Abstract

A novel synthetic approach was developed for the construction of the 1,2,3,4-tetrahydroisoquinoline framework possessing varied functions. The synthetic strategy was based on oxidative ring opening of some indene derivatives through their C=C bond, followed by double reductive amination of the dicarbonyl intermediates with various primary alkyl- or fluoroalkylamines.

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