Remete, Attila Márió and Nonn, Melinda and Fustero, Santos and Fülöp, Ferenc and Kiss, Loránd (2018) Synthesis of fluorinated amino acid derivatives through late-stage deoxyfluorinations. TETRAHEDRON. pp. 6367-6418. ISSN 0040-4020
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Abstract
Fluorine chemistry has represented a hot topic in drug research over the last decade. Because of their pharmaceutical potential, fluorine-containing amino acids and related derivatives have acquired high importance among medicinal chemists. Therefore their synthesis and the development of various synthetic methods for these types of molecular scaffolds have gained increasing interest in synthetic organic chemistry. The current review focuses on synthetic protocols towards fluorine-containing amino acid derivatives through late-stage fluorination with various nucleophilic reagents, describing the access of various open-chain and cyclic a-, b-, g-amino acid derivatives
Item Type: | Article |
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Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD04 Organic chemistry / szerves kémia |
Depositing User: | Dr Loránd Kiss |
Date Deposited: | 19 Nov 2018 10:58 |
Last Modified: | 19 Nov 2018 10:58 |
URI: | http://real.mtak.hu/id/eprint/87164 |
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