Chinopoulos, Christos (2018) Mitochondrial permeability transition pore: Back to the drawing board. NEUROCHEMISTRY INTERNATIONAL, 117 (SI). pp. 49-54. ISSN 0197-0186
|
Text
3294518_2018_Mitochondrial_permeability_transition_pore_Back_to_the_drawing_board.pdf Download (919kB) | Preview |
Abstract
Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere. © 2017 Elsevier Ltd.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Dimers; Bioenergetics; ATP SYNTHASE; C-subunit ring; |
| Subjects: | Q Science / természettudomány > QH Natural history / természetrajz > QH301 Biology / biológia |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 23 Jan 2019 11:08 |
| Last Modified: | 23 Jan 2019 11:08 |
| URI: | http://real.mtak.hu/id/eprint/90353 |
Actions (login required)
 |
Edit Item |
