The extent of PXE skin changes is related to cardiovascular complications and visual loss: a cross-sectional study

Navasiolava, N. and Gnanou, M. and Douillard, M. and Saulnier, P. and Arányi, T. and Erran, J.-M. and Henni, S. and Humeau, H. and Leftheriotis, G. and Martin, L. (2018) The extent of PXE skin changes is related to cardiovascular complications and visual loss: a cross-sectional study. BRITISH JOURNAL OF DERMATOLOGY, 180 (1). pp. 207-208. ISSN 0007-0963

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Abstract

Pseudoxanthoma elasticum (PXE) is a genetic multisystem disorder with cutaneous, ophthalmological and cardiovascular (CV) involvement(1, 2, 3) . Having the capacity to predict the natural progression of PXE within various systems would improve preventive care in those patients at elevated risk of CV or ophthalmological complications. Yet, the means required to predict PXE progression are still lacking today. It is yet to be established whether each body system evolves at its own pace, however skin is typically involved earlier than other systems(4) . PXE skin lesions appear mainly in the first two decades of life; the initial manifestations are usually located at the neck and progressively extend to other skin areas. This extension is mostly over around 30 years old (y/o).(5) CV and ophthalmological complications may develop later. This article is protected by copyright. All rights reserved.

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