Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone

Mészáros, János Péter and Poljarević, Jelena M. and Gál, Gyula Tamás and May, Nóra Veronika and Spengler, Gabriella and Enyedy, Éva Anna (2019) Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone. JOURNAL OF INORGANIC BIOCHEMISTRY, 195. pp. 91-100. ISSN 0162-0134

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Abstract

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η 6 ‑p‑cymene), Ru(η 6 ‑toluene) complexes were also studied. 1 H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η 6 ‑p‑cymene) > Ru(η 6 ‑toluene) > Rh(η 5 -C 5 Me 5 ). Despite this order, the highest extent of complex formation is seen for the Rh(η 5 -C 5 Me 5 ) complexes at pH 7.4. Formation constant of [Rh(η 5 -C 5 Me 5 )(H 2 curcumin)(H 2 O)] + reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations. © 2019

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