REAL

Items where Author is "Mező, Gábor"

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Item Type | No Grouping
Number of items: 56.

Article

Szabó, Ildikó and Biri-Kovács, Beáta and Vári, Balázs and Ranđelović, Ivan and Vári-Mező, Diána and Juhász, Éva and Halmos, Gábor and Bősze, Szilvia and Tóvári, József and Mező, Gábor (2024) Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (2). No.-1095. ISSN 1661-6596 (print); 1422-0067 (online)

Mező, Gábor (2023) Nekrológ egy igaz emberről. MAGYAR KÉMIAI FOLYÓIRAT - KÉMIAI KÖZLEMÉNYEK (1997-), 129 (3-4). pp. 94-95. ISSN 1418-9933

Dürvanger, Zsolt and Boros, Eszter and Nagy, Zoltán Attila and Hegedüs, Rózsa and Megyeri, Márton and Dobó, József and Gál, Péter and Schlosser, Gitta (Vácziné) and Ángyán, Annamária F. and Gáspári, Zoltán and Perczel, András and Harmat, Veronika and Mező, Gábor and K. Menyhárd, Dóra and Pál, Gábor (2022) Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides. ACS CHEMICAL BIOLOGY, 17. 969 -986. ISSN 1554-8929

Kis, Adrienn and Dénes, Noémi and Szabó P, Judit and Arató, Viktória and Jószai, István and Enyedi, Kata Nóra and Lakatos, Szilvia and Garai, Ildikó and Mező, Gábor and Kertész, István and Trencsényi, György (2020) In vivo assessment of aminopeptidase N (APN/CD13) specificity of different 68Galabelled NGR derivatives using PET/MRI imaging. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 589. p. 119881. ISSN 0378-5173

Pethő, Lilla and Kasza, György and Lajkó, Eszter and Láng, Orsolya and Kőhidai, László and Iván, Béla and Mező, Gábor (2020) Amphiphilic drug–peptide–polymer conjugates based on poly(ethylene glycol) and hyperbranched polyglycerol for epidermal growth factor receptor targeting: the effect of conjugate aggregation on in vitro activity. SOFT MATTER, 16 (24). pp. 5759-5769. ISSN 1744-683X (print); 1744-6848 (online)

Kiss, Krisztina and Biri-Kovács, Beáta and Szabó, Rita and Ranđelović, Ivan and Enyedi, Kata Nóra and Schlosser, Gitta and Orosz, Ádám and Kapuvári, Bence and Tóvári, József and Mező, Gábor (2019) Sequence modification of heptapeptide selected by phage display as homing device for HT-29 colon cancer cells to improve the anti-tumour activity of drug delivery systems. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 176. pp. 105-116. ISSN 0223-5234 (In Press)

Pethő, Lilla and Murányi, József and Pénzes, Kinga and Gurbi, Bianka and Brauswetter, Diána and Halmos, Gábor and Csík, Gabriella and Mező, Gábor (2019) Suitability of GnRH Receptors for Targeted Photodynamic Therapy in Head and Neck Cancers. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (20). pp. 1-17. ISSN 1661-6596 (print); 1422-0067 (online)

Rivas, Paula López and Ranđelović, Ivan and Dias, André Raposo Moreira and Pina, Arianna and Arosio, Daniela and Tóvári, József and Mező, Gábor and Dal Corso, Alberto and Pignatoro, Luca and Genarri, Cesare (2018) Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Lysosomally Cleavable Linkers and αVβ3-Integrin Ligands for Tumor Targeting. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018 (23). pp. 2902-2909. ISSN 1434-193X

Tripodi, Andrea Angelo Pierluigi and Tóth, Szilárd and Enyedi, Kata Nóra and Schlosser, Gitta and Szakács, Gergely and Mező, Gábor (2018) Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property. Beilstein Journal of Organic Chemistry, 14. pp. 911-918. ISSN 1860-5397

Kormos, Attila and Koehler, Christine and Fodor, A. Eszter and Rutkai, R. Zsófia and Martin, M. E. and Mező, Gábor and Kele, Péter (2018) Bistetrazine-Cyanines as Double-Clicking Fluorogenic Two-Point Binder or Crosslinker Probes. CHEMISTRY-A EUROPEAN JOURNAL, 24 (35). pp. 8841-8847. ISSN 0947-6539

Tripodi, Andrea Angelo Pierluigi and Tóth, Szilárd and Enyedi, Kata Nóra and Schlosser, Gitta (Vácziné) and Szakács, Gergely and Mező, Gábor (2018) Development of novel cyclic NGR peptide-daunomycin conjugates with dual targeting property. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 14. pp. 911-918. ISSN 1860-5397

Schuster, Sabine and Biri, Beáta and Szeder, Bálint and Farkas, Viktor and Buday, László and Szabó, Zsuzsanna and Halmos, Gábor and Mező, Gábor (2018) Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2018 (14). pp. 756-771. ISSN 1860-5397

Orosz, Ádám and Bősze, Szilvia and Mező, Gábor and Szabó, Ildikó and Herényi, Levente and Csik, Gabriella (2017) Oligo‑ and polypeptide conjugates of cationic porphyrins: binding, cellular uptake, and cellular localization. Amino Acids, 49. pp. 1263-1276. ISSN 1438-2199

Sebestyén, Mónika and Szabó, Rita and Kőhidai, László and Pállinger, Éva and Mező, Gábor and Kóczán, György and Hudecz, Ferenc (2017) Synthesis, conformation and cytotoxicity of new, branched polymeric polypeptides containing hydrophobic amino acid or arginine moiety. STRUCTURAL CHEMISTRY, 28 (2). pp. 527-537. ISSN 1040-0400

Murányi, József and Varga, Attila and Gurbi, Bianka and Gyulavári, Pál and Mező, Gábor and Vántus, Tibor (2017) In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues. Journal of Visualized Experiments (121). pp. 1-9. ISSN 1940-087X

Szabó, Rita and Sebestyén, Mónika and Kóczán, György and Orosz, Ádám and Mező, Gábor and Hudecz, Ferenc (2017) Cellular Uptake Mechanism of Cationic Branched Polypeptides with Poly[L‑Lys] Backbone. ACS Combinatorial Science, 19 (4). pp. 246-254. ISSN 2156-8952

Demeter, Orsolya and Kormos, Attila and Koehler, Christine and Mező, Gábor and Németh, Krisztina and Kele, Péter and Takács, Levente B. and Lemke, Edward A. (2017) Bisazide Cyanine Dyes as Fluorogenic Probes for Bis-cyclooctynylated Peptide Tags and as Fluorogenic Crosslinkers of Cyclooctynylated Proteins. BIOCONJUGATE CHEMISTRY, in pre. in press. ISSN 1043-1802

Enyedi, Kata N. and Tóth, Szilárd and Szakács, Gergely and Mező, Gábor (2017) NGR-peptide-drug conjugates with dual targeting properties. PLOS ONE, 12 (6). pp. 1-18. ISSN 1932-6203

Orosz, Ádám Péter and Bősze, Szilvia and Mező, Gábor and Szabó, Ildikó and Herényi, Levente and Csik, Gabriella (2017) Oligo- and polypeptide conjugates of cationic porphyrins: binding, cellular uptake, and cellular localization. AMINO ACIDS, 49 (7). pp. 1263-1276. ISSN 0939-4451

Murányi, József and Gyulavári, Pál and Varga, Attila and Bökönyi, Györgyi and Tanai, Henriette and Vántus, Tibor and Pap, Domonkos and Ludányi, Krisztina and Mező, Gábor and Kéri, György (2016) Synthesis, characterisation and systematic comparison of FITC-labelled GnRH-I, -II and -III analogues on various tumour cells. JOURNAL OF PEPTIDE SCIENCE, 22 (8). pp. 552-560. ISSN 1075-2617

Demeter, O. and Fodor, E. A. and Kállay, M. and Mező, Gábor and Németh, K. and Kele, Péter (2016) A Double-Clicking Bis-Azide Fluorogenic Dye for Bioorthogonal Self-Labeling Peptide Tags. Chemistry, A European Journal, 22 (18). pp. 6382-6388. ISSN 0947-6539, ESSN: 1521-3765

Kapuvári, Bence and Schulz, Ákos and Hegedüs, Rózsa and Szabó, Ildikó and Manea, Marilena and Vincze, Borbála and Tóvári, József and Gacs, Alexandra and Tejeda, Miguel and Gaál, Dezső and Mező, Gábor (2015) Módosított GnRH-III-antraciklin biokonjugátumok daganat növekedést gátló hatásának tanulmányozása in vivo szubkután vs. ortotopikus rendszerekben. Magyar Onkológia, 59 (4). pp. 310-318. ISSN 0025-0244

Hegedüs, Rózsa and Pauschert, Aline and Orbán, Erika and Szabó, Ildikó and Andreu, David and Marquardt, Andreas and Mező, Gábor and Manea, Marilena (2015) Modification of Daunorubicin-GnRH-III Bioconjugates With Oligoethylene Glycol Derivatives to Improve Solubility and Bioavailability for Targeted Cancer Chemotherapy. Peptide Science, 104 (3). pp. 167-177. ISSN 1097-0282

Szabó, Ildikó and Bősze, Szilvia and Orbán, Erika and Sipos, Éva and Halmos, Gábor and Kovács, Magdolna and Mező, Gábor (2015) Comparative in vitro biological evaluation of daunorubicin containing GnRH-I and GnRH-II conjugates developed for tumor targeting. JOURNAL OF PEPTIDE SCIENCE, 21 (5). pp. 426-435. ISSN 1075-2617

Enyedi, Kata N. and Czajlik, András and Knapp, Krisztina and Láng, András and Majer, Zsuzsa and Lajkó, Eszter and Kőhidai, László and Perczel, András and Mező, Gábor (2015) Development of Cyclic NGR Peptides with Thioether Linkage:Structure and Dynamics Determining Deamidation and Bioactivity. Journal of Medicinal Chemistry, 589. pp. 1806-1817. ISSN 0022-2623

Horváti, Kata and Bacsa, B. and Szabó, N. and Fodor, K. and Balka, Gy. and Rusvai, M. and Kiss, É. and Mező, Gábor and Grolmusz, V. and Vértessy G., Beáta and Hudecz, Ferenc and Bősze, Szilvia (2015) Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models. TUBERCULOSIS, 95 (1). pp. 207-211. ISSN 1472-9792

Castillo, Gabriela and Pribransky, Kinga and Mező, Gábor and Kocsis, László and Csámpai, Antal and Németh, Krisztina and Keresztes, Zsófia and Hianik, Tibor (2015) Electrochemical and Photometric Detection of Plasmin by Specific Peptide Substrate. Electroanalysis, 27. pp. 789-798. ISSN 1040-0397, ESSN: 1521-4109

Máté, Gábor and Kertész, István and Enyedi, Kata N. and Mező, Gábor and Angyal, János and Vasas, Nikolett and Kiss, Adrienn and Szabó, Éva and Emri, Miklós and Bíró, Tamás and Galuska, László and Trencsényi, György (2015) In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 69. pp. 61-71. ISSN 0928-0987

Szabados, L. and Cseh, B. and Kovacs, J. and Csak, B. and Dozsa, A. and Szabo, G. M. and Simon, A. E. and Borkovits, T. and Kiss, L. L. and Jankovics, I. and Mező, Gábor (2014) Discovery of the spectroscopic binary nature of the classical Cepheids FN Aql and V1344 Aql. Monthly Notices of the Royal Astronomical Society, 442 (4). pp. 3155-3161. ISSN 0035-8711

Cserép, Gergely B. and Enyedi, Kata E. and Demeter, Attila and Mező, Gábor and Kele, Péter (2013) NIR mega-Stokes fluorophores for bioorthogonal labeling and energy transfer systems - An efficient quencher for daunomycin. Chemistry an Asian Journal, 8 (2). pp. 494-502. ISSN 1861-471X

Orosz, Ádám and Mező, Gábor and Herényi, Levente and Habdas, Jan and Majer, Zsuzsa and Mysliwa-Kurdziel, Beata and Tóth, Katalin and Csík, Gabriella (2013) Binding of new cationic porphyrin–tetrapeptide conjugates to nucleoprotein complexes. Biophysical Chemistry, 177. pp. 14-23. ISSN 0301-4622

Lajkó, Eszter and Szabó, Ildikó and Andódy, Katalin and Pungor, András and Mező, Gábor and Kőhidai, László (2013) Investigation on chemotactic drug targeting (chemotaxis and adhesion) inducer effect of GnRH-III derivatives in Tetrahymena and human leukemia cell line. JOURNAL OF PEPTIDE SCIENCE, 19 (1). pp. 46-58. ISSN 1075-2617

Díaz, Emilia and Kőhidai, László and Ríos, Arturo and Vanegas, Oriana and Silva, Adrian and Szabó, Rita and Mező, Gábor and Hudecz, Ferenc and Ponte-Sucre, Alicia (2013) LEISHMANIA BRAZILIENSIS : Cytotoxic, cytostatic and chemotactic effects of poly-lysine-Methotrexate-conjugates. Experimental Parasitology, 135 (1). pp. 134-141. ISSN 0014-4894

Söptei, Balázs and Naszályi Nagy, Lívia and Baranyai, Péter and Szabó, Ildikó and Mező, Gábor and Hudecz, Ferenc and Bóta, Attila (2013) On the selection and design of proteins and peptide derivatives for the production of photoluminescent, red-emitting gold quantum clusters. Gold Bulletin. ISSN 2190-7579

Schreier, Verena Natalie and Mező, Gábor and Orbán, Erika and Dürr, Claudia and Marquardt, Andreas and Manea, Marilena (2013) Synthesis, enzymatic stability and in vitro cytostatic effect of Daunorubicin-GnRH-III derivative dimers. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23 (7). pp. 2145-2150. ISSN 0960-894X

Manea, Marilena and Mező, Gábor (2013) lGnRH-III - a Promising Candidate for Anticancer Drug Development. Protein and Peptide Letters, 20 (4). pp. 439-449. ISSN ISSN: 1875-5305 (Online), ISSN: 0929-8665 (Print)

Tátrai, Péter and Sági, Bernadett and Szigeti, Anna and Szepesi, Áron and Szabó, Ildikó and Bősze, Szilvia and Kristóf, Zoltán and Markó, Károly and Szakács, Gergely and Urbán, István and Mező, Gábor and Német, Katalin (2013) A novel cyclic RGD-containing peptide polymer improves serum-free adhesion of adipose tissue-derived mesenchymal stem cells to bone implant surfaces. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24 (2). pp. 479-488. ISSN 0957-4530

Balogh, Ádám and Bősze, Szilvia and Horváti, Kata and Mező, Gábor and Kéki, Sándor and Nagy, Lajos and Bokodi, Géza and Szabó, Miklós and Vásárhelyi, Barna (2010) A vasháztartást szabályzó hepcidin kimutatása és szerepe a perinatalis vasháztartásban = Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis. Orvosi Hetilap, 151 (3). pp. 83-91. ISSN 0030-6002

Szabó, Rita and Mező, Gábor and Pállinger, Éva and Kovács, Péter and Kőhidai, László and Bősze, Szilvia and Hudecz, Ferenc (2008) In VitroCytotoxicity, Chemotactic Effect, and Cellular Uptake of Branched Polypeptides with Poly[l-Lys] Backbone by J774 Murine Macrophage Cell Line. Bioconjugate Chemistry, 19 (5). pp. 1078-1086. ISSN 1043-1802 (print), 1520-4812 (online)

Book Section

Lajkó, Eszter and Hegedüs, Rózsa and Mező, Gábor and Kőhidai, László (2020) Comparison of the apoptotic effects of different GnRH-based conjugates with or without butyrated Lys in position 4 on colon carcinoma cells. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 17-22. ISBN 978-963-489-286-1

Dókus, Endre Levente and Lajkó, Eszter and Láng, Orsolya and Mező, Diána and Szász, Zsófia and Takács, Angéla and Kőhidai, László and Schlosser, Gitta (Vácziné) and Ranđelović, Ivan and Tóvári, József and Mező, Gábor (2020) Design, synthesis and characterization of Pancreatic Ductal Adenocarcinoma (PDAC) targeting antitumor daunomycin-peptide conjugates. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 34-38.

Tripodi, Andrea Angelo Pierluigi and Enyedi, Kata Nóra and Biri-Kovács, Beáta and Ranđelović, Ivan and Tóth, Szilárd and Szeder, Bálint and Szakács, Gergely and Tóvári, József and Mező, Gábor (2020) Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 28-33. ISBN 978-963-489-286-1

Pethő, Lilla and Mező, Gábor and Schlosser, Gitta (Vácziné) (2020) Effect of ionization conditions in electrospray ionization mass spectrometry of daunorubicin-tuftsin peptide conjugates. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 60-64. ISBN 978-963-489-286-1

Oláh-Szabó, Rita and Jernei, Tamás and Szabó, Ildikó and Mező, Gábor and Csámpai, Antal (2020) In vitro anti-tumor effect of cinchona-chalcone hybrids with 1,4- or 1,5-disubstituted 1,2,3-triazole linker. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 70-74. ISBN 978-963-489-286-1

Schuster, Sabine and Biri-Kovács, Beáta and Ranđelović, Ivan and Tóvári, József and Mező, Gábor (2020) New GnRH-III derivative as homing peptide for potential drug targeting in cancer therapy. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 10-16. ISBN 978-963-489-286-1

Kiss, Krisztina and Biri-Kovács, Beáta and Szabó, Rita and Enyedi, Kata Nóra and Murányi, József and Schlosser, Gitta (Vácziné) and Ranđelović, Ivan and Tóvári, József and Mező, Gábor (2020) Optimation of homing peptide sequence selected by phage display for HT-29 colon cancer cells to improve the antitumor activity. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 5-9. ISBN 978-963-489-286-1

Bánóczi, Zoltán and Szabó, Ildikó and Mező, Gábor (2020) Optimization of the structure of targeted Daunomycin conjugates against non-small cell lung cancer. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 45-49. ISBN 978-963-489-286-1

Mező, Gábor (2020) Preface: Development of bioconjugates and their module constructs for targeted therapy of cancers with high mortality. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 3-4. ISBN 978-963-489-286-1

Biri-Kovács, Beáta and Adorján, Afrodité and Szabó, Ildikó and Szeder, Bálint and Bősze, Szilvia and Mező, Gábor (2020) Structural and binding characteristics of HER2 receptor targeting peptides. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 23-27.

Szabó, Ildikó and Bősze, Szilvia and Mező, Gábor (2020) Synthesis and in vitro evaluation of drug containing melanoma specific peptide conjugates. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 39-44. ISBN 978-963-489-286-1

Schlosser, Gitta (Vácziné) and Al-Majidi, Mohammed and Borbély, Adina Noémi and Pethő, Lilla and Szabó, Dániel and Dókus, Endre Levente and Mező, Gábor (2020) Tandem mass spectrometry of daunorubicin-containing peptide conjugates. In: Development of bioconjugates and their modul constructs for targeted therapy of cancers with high mortality. Eötvös Loránd Tudományegyetem, Budapest, pp. 55-59. ISBN 978-963-489-286-1

Monograph

Mező, Gábor and Bősze, Szilvia and Csuka, Orsolya and Kovács, Magdolna and Kőhidai, László and Láng, Orsolya and Schlosser, Gitta (Vácziné) and Szabó, Ildikó and Vásárhelyi, Barna and Vincze, Borbála (2013) Célzott terápiára alkalmas új peptidkonjugátumok szintézise és alkalmazása rosszindulatú daganatok kezelésében. = Development of new peptide conjugates for targeted therapy of cancer. Project Report. OTKA.

Mező, Gábor and Csuka, Orsolya and Gaál, Dezső and Jakab, Annamária and Kovács, Magdolna and Láng, Orsolya and Reményi, Judit and Schlosser, Gitta (Vácziné) and Vincze, Borbála (2009) Hatékony tumorellenes készítmények előállítása target és drug molekulák kombinációjával = Synthesis of effective antitumoricidal compounds with the combination of target and drug molecules. Project Report. OTKA.

Hudecz, Ferenc and Bősze, Szilvia and Kóczán, György and Kőhidai, László and Mező, Gábor and Szabó, Rita and Rajnavölgyi, Éva and Reményi, Judit and Tugyi, Regina (2007) Epitópok illetve antimikrobiális hatású peptidek, peptidszármazékok célzott bevitele makrofág típusú sejtekbe = Targeting of epitope or antimicrobial peptides and derivatives to macrophages. Project Report. OTKA.

Vékey, Károly and Drahos, László and Imre, Tímea and Mező, Gábor and Schlosser, Gitta (Vácziné) and Takáts, Zoltán (2007) Új tömegspektrometriás módszerek kifejlesztése és alkalmazása a peptid- és fehérjekutatásban = Development and application of mass spectrometric techniques for the analysis of peptides and proteins. Project Report. OTKA.

Conference or Workshop Item

Bánóczi, Zoltán and Csik, Gabriella and Orbán, Erika and Magyar, Anna and Uray, Katalin and Schlosser, Gitta (Vácziné) and Bősze, Szilvia and Mező, Gábor and Sármay, Gabriella and Hudecz, Ferenc (2014) Alteration of functional properties of covalently attached entity by conjugation with oligo- or polypeptide. In: 4th Asia-Pacific International Peptide Symposium with the 50th Japanese Peptide Symposium, 2013. november 6-8., Osaka, Japán.

This list was generated on Fri Apr 19 06:15:06 2024 CEST.