Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus

Peng, Gao-Yang and Kurtán, Tibor and Mándi, Attila and He, Jing and Cao, Zheng-Yu and Tang, Hua and Mao, Shui-Chun and Zhang, Wen (2021) Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus. Marine Drugs, 19. p. 281. ISSN 1660-3397

Preview

Text MarDrugs_2021_19_281_PengGY.pdf - Published Version Download (3MB) | Preview

Abstract

Three new p-terphenyl derivatives, named 400-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca2+ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure–activity relationship was discussed.

Actions (login required)

Edit Item