Alternarin A, a Drimane Meroterpenoid, Suppresses Neuronal Excitability from the Coral-Associated Fungi Alternaria sp. ZH-15

Wang, Hong-Liang and Li, Ran and Li, Jiao and He, Jing and Cao, Zheng-Yu and Kurtán, Tibor and Mándi, Attila and Zheng, Gui-Liang and Zhang, Wen (2020) Alternarin A, a Drimane Meroterpenoid, Suppresses Neuronal Excitability from the Coral-Associated Fungi Alternaria sp. ZH-15. Organic Letters, 22. pp. 2295-2298. ISSN 1523-7060

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Abstract

Alternarin A (1), a rearranged drimane meroterpenoid characterized by a thioglycerate moiety, was isolated together with two known analogues from the coralassociated fungi Alternaria sp. ZH-15. Its structure was determined based on spectroscopic analysis, modified Mosher’s method, and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, compound 1 effectively inhibited the activity of spontaneous synchronous Ca2+ oscillations and 4-aminopyridine induced epileptic discharges in the low micromolar concentration range.

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