Juhász, Gábor (2012) Interpretation of bafilomycin, pH neutralizing or protease inhibitor treatments in autophagic flux experiments: novel considerations. AUTOPHAGY, 8 (12). pp. 1875-6. ISSN 1554-8627
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Abstract
Recent publications showed that the kinase MTOR localizes to lysosomes and its activation depends on amino acids inside the lysosomal lumen, implying that autophagic protein degradation is a positive regulator of MTOR in this setting. Since decreased MTOR activity results in autophagy induction, drug treatments that block autolysosomal degradation (a commonly used technique to estimate autophagic flux) may actually interfere not only with lysosomal breakdown, but also increase autophagosome generation through impaired MTOR signaling.
Item Type: | Article |
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Subjects: | Q Science / természettudomány > Q1 Science (General) / természettudomány általában |
Depositing User: | Dr. Gabor Juhasz |
Date Deposited: | 18 Sep 2014 09:25 |
Last Modified: | 18 Sep 2014 09:25 |
URI: | http://real.mtak.hu/id/eprint/15365 |
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