Reduced loss aversion in value-based decision-making and edge-centric functional connectivity in patients with internet gaming disorder

Hong, Wei and Liang, Peipeng and Pan, Yu and Jin, Jia and Luo, Lijuan and Li, Ying and Jin, Chen and Lü, Wanwan and Wang, Min and Liu, Yan and Chen, Hui and Gou, Huixing and Wei, Wei and Ma, Zhanyu and Tao, Ran and Zha, Rujing and Zhang, Xiaochu (2023) Reduced loss aversion in value-based decision-making and edge-centric functional connectivity in patients with internet gaming disorder. Journal of Behavioral Addictions, 12 (2). pp. 458-470. ISSN 2062-5871

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Abstract

Background and aims: Impaired value-based decision-making is a feature of substance and behavioral addictions. Loss aversion is a core of value-based decision-making and its alteration plays an important role in addiction. However, few studies explored it in internet gaming disorder patients (IGD). Methods: In this study, IGD patients (PIGD) and healthy controls (Con-PIGD) performed the Iowa gambling task (IGT), under functional magnetic resonance imaging (fMRI). We investigated group differences in loss aversion, brain functional networks of node-centric functional connectivity (nFC) and the overlapping community features of edge-centric functional connectivity (eFC) in IGT. Results: PIGD performed worse with lower average net score in IGT. The computational model results showed that PIGD significantly reduced loss aversion. There was no group difference in nFC. However, there were sig- nificant group differences in the overlapping community features of eFC 1 . Furthermore, in Con-PIGD, loss aversion was positively correlated with the edge community profile similarity of the edge 2 between left IFG and right hippocampus at right caudate. This relationship was suppressed by response con- sistency 3 in PIGD. In addition, reduced loss aversion was negatively correlated with the promoted bottom-to-up neuromodulation from the right hippocampus to the left IFG in PIGD. Discussion and conclusions: The reduced loss aversion in value-based decision making and their related edge-centric functional connectivity support that the IGD showed the same value-based decision-making deficit as the substance use and other behavioral addictive disorders. These findings may have important significance for understanding the definition and mechanism of IGD in the future.

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