Dömötör, Orsolya and Mathuber, Marlene and Kowol, Christian R. (2024) In vitro biodistribution studies on clinically approved FGFR inhibitors ponatinib, nintedanib, erlotinib and the investigational inhibitor KP2692. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 192. ISSN 0928-0987
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Abstract
Binding towards human serum albumin (HSA) and α1-acid glycoprotein (AGP) of three approved fibroblast growth factor receptor (FGFR) inhibitors ponatinib (PON), nintedanib (NIN) and erdafitinib (ERD), as well as the experimental drug KP2692 was studied by means of spectrofluorometric and UV-visible spectrophotometric methods. Additionally, proton dissociation processes, lipophilicity, and fluorescence properties of these four molecules were investigated in detail.
| Item Type: | Article |
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| Uncontrolled Keywords: | Protein Binding; spectrofluorometry; Binding constant; FGF/FGFR; blood serum distribution; |
| Subjects: | Q Science / természettudomány > QD Chemistry / kémia > QD01 Analytical chemistry / analitikai kémia Q Science / természettudomány > QD Chemistry / kémia > QD03 Inorganic chemistry / szervetlen kémia R Medicine / orvostudomány > RM Therapeutics. Pharmacology / terápia, gyógyszertan |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 05 Dec 2023 12:49 |
| Last Modified: | 05 Dec 2023 12:49 |
| URI: | http://real.mtak.hu/id/eprint/181797 |
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