TRP channels in dermatology

Oláh, Attila and Szöllősi, Attila and Tóth, Balázs István (2024) TRP channels in dermatology. In: TRP Channels as Therapeutic Targets : Advances in Basic Science and Clinical Use. Academic Press as an imprint of Elsevier, Waltham (MA), pp. 365-385. ISBN 9780443186530

Text real_BCh3_TRPchannelsindermatologyOlah2024.pdf - Published Version Restricted to Repository staff only Download (238kB) | Request a copy

Abstract

The skin is considered as one of our biggest organs with versatile functions. It forms a complex barrier protecting our body against physical and chemical insults and pathogenic invasion, is involved in complex immunological responses and endocrine regulation, regulates body temperature, and transduces somatosensory stimuli such as temperature, pain, and itch. These diverse functions are served by a complex structure involving the barrier forming epidermal keratinocytes, different appendages, various immune cells, subcutaneous adipose tissue, skin vessels, and a dense network of somatosensory fibersdmany of which express TRP channels. In this chapter, we will restrict the discussion mainly to barrier forming structures, skin-specific features, and selected dermatological conditions taking into account that other chapters in this book discuss the detailed role of TRP channels in somatosensory functions, vascular biology, as well as in cancerous diseases.

Actions (login required)

Edit Item