Li, Q. and Wu, Z. and Sun, R. and Liu, X. and Luo, J. and Chen, X. and Zheng, J. and Liu, R. (2025) Improvement in DSS induced acute enteritis in mice with supplementation of bifidobacteria. ACTA ALIMENTARIA, 54 (1). pp. 84-95. ISSN 0139-3006
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Abstract
Bifidobacteria can maintain the ecological balance of intestinal microorganisms and are closely linked to the onset and progression of acute enteritis. Present research aimed to investigate the alleviation of DSSinduced acute enteritis by bifidobacteria. In vivo colonoscopy was performed in mice to observe the colorectal mucosa and the pathological damage of colon tissue and the colonic expression of tight junction proteins (Occludin, Claudin-1, ZO-1) and inflammatory factors (TNF-α, IL-1b, IL-6). The colon mucosa tissue samples were collected for bacterial 16S DNA sequencing and transcriptome sequencing. The intervention of bifidobacteria could effectively alleviate the trend of weight loss and colonic trauma in mice with DSS-induced acute enteritis. The bifidobacteria effectively restored expression of tight junction proteins (Occludin, Claudin-1, and ZO-1) and decreased expression of pro-inflammatory factors (TNF-α, IL-1b, IL-6). Bifidobacterium longum proved to be the most effective (P < 0.05). The altered composition of gut microbiota was reflected in the increase of the relative abundances of Dubosiella spp. in the B. longum treated group. The results suggested that bifidobacteria could repair intestinal barrier function, relieve the colon inflammation, and improve intestinal microbiota disorder; and B. longum demonstrated the best efficacy in mice with DSS-induced acute enteritis.
Item Type: | Article |
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Uncontrolled Keywords: | acute enteritis, bifidobacteria, intestinal microbes, tight junction protein, transcriptomics analysis |
Subjects: | T Technology / alkalmazott, műszaki tudományok > TX Home economics / háztartástan > TX642-TX840 Food sciences / élelmiszertudomány |
Depositing User: | Dorottya Cseresnyés |
Date Deposited: | 24 Mar 2025 07:51 |
Last Modified: | 24 Mar 2025 07:51 |
URI: | https://real.mtak.hu/id/eprint/217179 |
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