Wheat bread supplemented with onion peel extract and onion powder ameliorates dyslipidaemia and inflammation in alloxan-induced diabetic rats

Masood, S. and Khan, I.S. and Ihsan, M.A. and Shahzad, K. and Iftikhar, F. and Khalil, P. and Basit, A. and Ullah, I. and Hameed, S. and Amin, N. and Ullah, A. and Hussain, Z. and Khalid, M. and Rehman, A.U. (2025) Wheat bread supplemented with onion peel extract and onion powder ameliorates dyslipidaemia and inflammation in alloxan-induced diabetic rats. ACTA ALIMENTARIA: AN INTERNATIONAL JOURNAL OF FOOD SCIENCE, 54 (3). pp. 508-519. ISSN 0139-3006

Text 066-article-p508.pdf - Published Version Restricted to Repository staff only Download (996kB)

Abstract

Recurrent hyperglycaemia and dyslipidaemia are primary challenges in diabetes management. This study investigated the hypolipidaemic and anti-inflammatory effects of wheat bread supplemented with 2% and 4% ethanolic onion ( Allium cepa L.) peel extract (OP) and 4% and 6% onion bulb powder (OB) in alloxan-induced diabetic rats. After 42 days of supplemented bread consumption, diabetic rats demonstrated significant reductions in blood glucose, insulin, and liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase (GGT). Additionally, the levels of triglycerides, total cholesterol, very-low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) significantly decreased, while high-density lipoprotein cholesterol (HDL-C) levels improved. Notably, breads containing 4% OP and 6% OB significantly reduced the levels of the inflammatory markers interleukin-1 beta (IL-1β) and monocyte chemoattractant protein-1 (MCP-1), indicating anti-inflammatory effect, though reductions in other inflammatory markers were not significant ( P < 0.01). The results suggest that both OP and OB, particularly at 4% and 6% concentrations, respectively, demonstrate strong potential for incorporation into functional foods aimed at managing hyperglycaemia, dyslipidaemia, and inflammation in patients with diabetes.

Actions (login required)

Edit Item