Antioxidant synergism and antagonism between tocotrienols, quercetin and rutin in model system

Nogala-Kałucka, M. and Dwiecki, K. and Siger, A. and Górnaś, P. and Polewski, K. and Ciosek, S. (2013) Antioxidant synergism and antagonism between tocotrienols, quercetin and rutin in model system. Acta Alimentaria, 42 (3). pp. 360-370. ISSN 0139-3006

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Abstract

The aim of the study was to reveal antioxidant synergism or antagonism between quercetin, rutin and selected tocotrienols in linoleic acid emulsion. The oxidative stress was generated by 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH) or CuSO4; the increase of the concentration of peroxidation products was monitored using fluorescence probe 2,7-dichlorofluorescein (DCF). The antioxidant activity of tested substances depends on the form of the antioxidant (aglycone, glycoside), its concentration, localization in the emulsion, and the factors generating oxidative stress. The synergistic effect occurred when the effectiveness of individual antioxidant was relatively weak and mainly when the concentration of antioxidants was in the physiologically significant range of 1 μM. We suggest that tocotrienols were regenerated by flavonoids. The synergism benefitted from the proximity of the localization of interacting antioxidants (e.g. the presence of one of the antioxidants at the oil-water interface).

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