Beneficial effect of moderate white wine consumption on insulin sensitivity in patients with metabolic syndrome

Ábel, T. and Blázovics, A. and Wimmer, A. and Bekő, G. and Gaál, B. and Blazics, B. and Eldin, M. and Fehér, J. and Szabolcs, I. and Lengyel, G. (2013) Beneficial effect of moderate white wine consumption on insulin sensitivity in patients with metabolic syndrome. Acta Alimentaria, 42 (4). pp. 631-639. ISSN 0139-3006

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Abstract

The effect of moderate alcohol consumption on insulin sensitivity is actually a topic of intense research nowadays. In this study we investigated the effect of moderate consumption of white wine in subjects with metabolic syndrome. Thirty-two patients with metabolic syndrome participated in this prospective, randomised, double-blind study. The subjects received either Müller-Thurgau (n=14) or Pintes (n=18) sort of wine for 4 weeks. Male and female subjects consumed 300 ml wine (30 g alcohol) and 200 ml wine (20 g alcohol) per day, respectively. Clinical and laboratory parameters were determined before and after the period of wine consumption. The HOMA-IR showed a significant decrease upon the consumption of both sorts of wine as compared to the baseline (Müller-Thurgau group: 1.85±2.1 vs. 1.06±0.6; P=0.03; Pintes group: 2.28±2.04 vs. 1.08±0.6; P=0.002). Four weeks of wine consumption lead to significant decreased of ALT (alanine aminotransferase; Müller-Thurgau group: P=0.003; Pintes group: P=0.002) and AST (aspartate aminotransferase; Müller-Thurgau group: P=0.003; Pintes group: P=0.02). Epidermal growth factor (EGF) levels increased significantly in both groups (Müller-Thurgau group: P=0.004; Pintes group: P=0.001). The plasma reducing capacity increased significantly upon the consumption of both sorts of wine (Müller-Thurgau group: P=0.002; Pintes group: P=0.001). In patients consuming Müller-Thurgau there was a significant decrease of total cholesterol (5.4±1.4 vs. 4.9±1.2 mmol l−1; P=0.006) and LDL-cholesterol (3.9±1.1 vs. 3.6±1.2 mmol l−1; P=0.04) levels. In the Pintes group we found no significant difference either in total cholesterol (5.1±0.6 vs. 5.0±0.7 mmol l−1; P=0.25) or LDL-cholesterol (3.6±0.6 vs. 3.6±0.6 mmol l−1; P=0.5) concentrations. The results of our study confirm that moderate consumption of white wine increases insulin sensitivity and EGF levels in persons with metabolic syndrome.

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