Fruits to potentiate the antibiotic activity: The effect of Eugenia uniflora and Eugenia jambolanum L. against MRSA

Coutinho, H. and Costa, J. and Falcão-Silva, V. and Siqueira-Júnior, J. and Lima, E. (2012) Fruits to potentiate the antibiotic activity: The effect of Eugenia uniflora and Eugenia jambolanum L. against MRSA. Acta Alimentaria, 41 (1). pp. 67-72. ISSN 0139-3006

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Abstract

Some Staphylococcus species are frequently recognized as etiological agents of many animal and human opportunistic infections. This is the first report testing the antibiotic resistance-modifying activity of Eugenia jambolanum and Eugenia uniflora against methicillin-resistant Staphylococcus aureus — MRSA strain. In this study, the ethanol extracts of Eugenia jambolanum L., Eugenia uniflora L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with aminoglycosides against an MRSA strain using microdilution method. Synergism between both extracts and all aminoglycosides assayed was demonstrated, except E. jambolanum and tobramycin. In the same form, synergism was observed between chlorpromazine and kanamicin, neomycin and tobramicin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. It is therefore suggested that extracts from E. uniflora L. and E. jambolanum L. could be used as a source of plant derived natural products to modify antibiotic activity of aminoglycosides.

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