Plasma endotoxin level of healthy donors

Nádházi, Z. and Takáts, A. and Offenmüller, K. and Bertók, L. (2002) Plasma endotoxin level of healthy donors. Acta Microbiologica et Immunologica Hungarica, 49 (1). pp. 151-157. ISSN 1217-8950

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Abstract

The plasma level of endotoxin was determined in 116 healthy blood donors. After a routine physical and laboratory investigations the endotoxin level was determined with Limulus amebocyte lysate assay (LAL-test) by the chromogenic kinetic method of Bio-Whittaker Co. (USA). Its sensitivity was 0.005-50 EU/ml. The plasma level of endotoxin in most of the healthy donors was less than 1 EU/ml (in the range of 0.01-1.0 EU/ml), but always measurable. The average ±S.D. was 0.128±0.215 EU/ml. Because of the high standard deviation and high range of values, the data were distributed into two groups with the means of 0.05±0.022 EU/ml and 0.294±0.186 EU/ml. The difference between the groups was significant (p<0.001). In conclusion, endotoxin can be measured in plasma of healthy individuals.

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