Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates

Indelicato, Serena and Bongiorno, David and Indelicato, Sergio and Drahos, László and Liveri, Vincenzo Turco and Turiák, Lilla and Vékey, Károly and Ceraulo, Leopoldo (2013) Degrees of freedom effect on fragmentation in tandem mass spectrometry of singly charged supramolecular aggregates of sodium sulfonates. JOURNAL OF MASS SPECTROMETRY, 48 (3). pp. 379-383. ISSN 1076-5174

Preview

Text KEZIRAT-Degrees of Freedom.pdf - Submitted Version Download (185kB) | Preview

Abstract

The characteristic collision energy (CCE) to obtain 50% fragmentation of positively and negatively single charged non-covalent clusters has been measured. CCE was found to increase linearly with the degrees of freedom (DoF) of the precursor ion, analogously to that observed for synthetic polymers. This suggests that fragmentation behavior (e.g. energy randomization) in covalent molecules and clusters are similar. Analysis of the slope of CCE with molecular size (DoF) indicates that activation energy of fragmentation of these clusters (loss of a monomer unit) is similar to that of the lowest energy fragmentation of protonated leucine-enkephalin. Positively and negatively charged aggregates behave similarly, but the slope of the CCE vs DoF plot is steeper for positive ions, suggesting that these are more stable than their negative counterparts.

Actions (login required)

Edit Item