Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues

Adamska-Bartlomiejczyk, Anna and Borics, Attila and Tömböly, Csaba and Dvorácskó, Szabolcs and Lisowski, Marek (2017) Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues. JOURNAL OF PEPTIDE SCIENCE, 23 (12). pp. 864-870. ISSN 1075-2617

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Abstract

Three novel morphiceptin analogs, in which Pro in position 2 and/or 4 was replaced by cis-4-aminoproline connected with the preceding amino acid through the primary amino group, were synthesized. The opioid receptor affinities, functional assay results, enzymatic degradation studies and experimental and in silico structural analysis of such analogs are presented. Copyright (c) 2017 European Peptide Society and John Wiley & Sons, Ltd.

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