Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

Balogh, Attila and Domokos, András and Farkas, Balázs and Farkas, Attila and Rapi, Zsolt and Kiss, Domokos and Nyiri, Zoltán and Eke, Zsuzsanna and Szakra, Györgyi and Örkényi, Róbert and Mátravölgyi, Béla and Faigl, Ferenc and Marosi, György and Nagy, Zsombor Kristóf (2018) Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning. Chemical Engineering Journal, 350. pp. 290-299. ISSN 1385-8947

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Abstract

Based on the concept of continuous manufacturing an end-to-end benchtop device was developed unprecedented for the production of solid drug dosage forms by connecting flow synthesis and formulation via electrospinning (ES). Together with the optimized two-step continuous-flow synthesis of acetylsalicylic acid (ASA) a water-soluble polymeric excipient (polyvinylpyrrolidone K30, PVPK30) was introduced. The resulting polymeric solution could be readily electrospun into solid nanofibers with high purity in one single step due to the excellent yet gentle drying effect of ES. The ASA-loaded fibers were electrostatically deposited onto a water-soluble pullulan sheet and the obtained double-layered films were continuously cut into orally dissolving webs (ODWs) as final dosage formulation. The synthesis as well as the dosing of the fibrous films were monitored by Process Analytical Technology (PAT) tools (IR and Raman spectroscopy) with active feedback on product quality. The successful coupling of flow synthesis and fiber formation confirms that ES enables versatile formulation of pharmaceuticals in future continuous production systems.

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