Synthesis of Phosphonates in a Continuous Flow Manner

Tóth, Nóra and Tajti, Ádám and Ladányi-Pára, Katalin and Bálint, Erika and Keglevich, György (2018) Synthesis of Phosphonates in a Continuous Flow Manner. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 194. pp. 285-286. ISSN 1042-6507 (In Press)

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Abstract

The synthesis of dialkyl H-phosphonates and α-aminophosphonates was studied in a continuous flow microwave reactor. Depending on the conditions, the alcoholysis of dialkyl H-phosphonates could be fine-tuned towards the mixed and the fully transesterified products. The continuous flow synthesis of α-aryl-α-aminophosphonates was elaborated utilizing the aza-Pudovik reaction of imines and dialkyl H-phosphonates, as well as the by the Kabachnik-Fields condensation of primary amines, benzaldehyde and >P(O)H reagents.

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