Mitrea, Adriana and Postolache, Parascheva and Man, Milena Adina and Motoc, Nicoleta Stefania and Sarkozi, Hedi-Katalin and Dumea, Elena and Zamfir, Viorica and Dantes, Elena (2023) A gyulladásos biomarkerek profilja SARS-CoV-2-fertőzésben szenvedő betegekben: mennyire tükrözik a tüdőérintettséget? ORVOSI HETILAP, 164 (41). pp. 1607-1615. ISSN 0030-6002
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Abstract
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with inflamma-tory and imaging alterations that vary depending on the disease severity.Objective: Monitoring changes in inflammatory biomarkers may offer insights into the extent of pulmonary altera-tions observed in chestCT. This study aimed to evaluate the profile of different inflammatory biomarkers, widely available and routinely measured in COVID-19 patients, and to determine whether alterations in their activity admission and discharge correlate with lung involvement assessed through CT scans. Methods: We conducted a retrospective observational study, wherein chest-CT scans were performed upon admission, and blood tests were conducted at admission and discharge. Treatment and monitoring adhered to national and ternational guidelines. Results: The profile of serum inflammatory markers (including values at admission and discharge, as well as their evolution during hospitalization) demonstrated a correlation with lung involvement as assessed by the total severity score. The high activity of serum inflammatory markers upon admission, accompanied by minimal changes during hospitalization, indicated a severe form of COVID-19 with notable lung involvement. While statistically significant differences were observed in C-reactive protein, fibrinogen, erythrocyte sedimentation rate, lactate dehydrogenase, and neutrophil-to-lymphocyte ratio, C-reactive protein emerged as the most reliable marker for assessing pulmonary involvement.Conclusion: Changes in serum inflammatory markers during hospitalization exhibited a weak to moderate negative correlation with the severity of lung involvement.
| Item Type: | Article |
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| Additional Information: | Konstancai „Ovidius” Egyetem, Általános Orvostudományi Kar, „Sf. Apostol Andrei” Konstanca Megyei Sürgősségi Kórház, Tüdőgyógyászati Osztály, Constanța, Romania Jászvásári „Grigore T. Popa” Orvosi és Gyógyszerészei Egyetem, Romania Kolozsvári „Iuliu Hațieganu” Orvosi és Gyógyszerészeti Egyetem, Általános Orvosi Kar, Tüdőgyógyászati Tanszék, „Leon Daniello” Pneumophtysiologiai Klinikai Kórház, Kolozsvár, Romania Marosvásárhelyi „George Emil Palade” Orvosi, Gyógyszerészeti, Tudomány- és Technológiai Egyetem, Tüdőgyógyászati Tanszék, Marosvásárhely, Romania Konstancai „Ovidius” Egyetem, Általános Orvostudományi Kar, Fertőző Betegségek Klinikai Kórháza, Constanța, Romania Konstancai „Ovidius” Egyetem, Általános Orvostudományi Kar, Pneumophtisiologiai Klinikai Kórház, Constanța, Romania Export Date: 17 January 2024 CODEN: ORHEA Correspondence Address: Motoc, N.S.Remenyik S. u. 4., D tömbház, 1. lakás, Kolozs megye, Romania; email: motoc_nicoleta@yahoo.com Chemicals/CAS: C reactive protein, 9007-41-4; fibrinogen, 9001-32-5; lactate dehydrogenase, 9001-60-9; lactate dehydrogenase A; Biomarkers; C-Reactive Protein |
| Uncontrolled Keywords: | INFLAMMATORY MARKERS; COVID-19; |
| Subjects: | R Medicine / orvostudomány > RZ Other systems of medicine / orvostudomány egyéb területei |
| SWORD Depositor: | MTMT SWORD |
| Depositing User: | MTMT SWORD |
| Date Deposited: | 01 Mar 2024 11:19 |
| Last Modified: | 01 Mar 2024 11:19 |
| URI: | https://real.mtak.hu/id/eprint/189420 |
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