Activation of the adductor in Anodonta-glochidia by N, N-dialkyl-tryptamines, 5-methoxy-tryptamine, β-adrenerg-antagonists, cocaine, scopolamine and other pharmacons

Lábos, Elemér (1970) Activation of the adductor in Anodonta-glochidia by N, N-dialkyl-tryptamines, 5-methoxy-tryptamine, β-adrenerg-antagonists, cocaine, scopolamine and other pharmacons. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 37. pp. 55-71. ISSN 0365-3005

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Abstract

Effects of activator substances were compared which elicit rhythmic or tonic adductor activity of Anodonta glochidia (see Table 1). It can be stated that: 1. DCI and pronethalol evoke a rhythm in 100 µM concentration cessing suddenly. A late tonus was observed independent from the rhythm. Propanolol in N ad does not evoke proper rhythmic activity. 2. DET leads to rhythm and a tonus of medium degree; 5-MeOTA evokes tonus almost without rhythm. Bufotenine in 1 mM concentration elicits a rhythm of high frequency. 3. The rhythm evoked by DCI can be influenced by indole compounds, secale-alkaloids, metabolic inhibitors (KCN, NaN₃, 2,4-DNP), cations (Na⁺, Li⁺, Ca²⁺). Typical inhibitions are caused by pyridoxale-5’-phosphate. nicotinic acid, vitamin B₆, INH and actomol. The cAMP potentiates slightly. 4. Cocaine evokes in 100-2000 µM concentrations a high frequency rhythm which is sometimes periodic; maximal activity is at 600 µM. 5. Scopolamine can produces a long-lasting rhythm (80 min). It is effective in 500-5000 µM concentration; maximum is at 1700 µM. 6. IPNA and dibenamine inhibits, 0.5-1 mM cAMP and catecholamines ~0.5 mM) potentiates the cocaine- or scopolamine-effects. A reserpinepreincubation slightly inhibits the late phase of cocaine-effect. 7. Yohimbine and ergometrine causes a low-frequency rhythm; the latter evokes a transient tonic closure as well. 8. EGYT-201 (spasmolyticum and local anaestheticum) elicits a shortlasting and very frequent rhythmic activity. True local anaesthetica (procaine and tetracaine) do not activate.

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