The effects of some adrenergic blocking agents on the mobilisation of fatty acids in lower vertebrates

Farkas, Tibor (1968) The effects of some adrenergic blocking agents on the mobilisation of fatty acids in lower vertebrates. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 35. pp. 127-133. ISSN 0365-3005

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Abstract

In agreement with our earlier observations it has been shown that catecholamines decrease the free fatty acid level of the blood in the fishes (Abramis brama L.) and in the marsh frog (Rana ridibunda L.) and the production of the free fatty acid in fish, frog and grass snake (Natrix natrix L.) adipose tissue in vitro. DCI alone has the same effect on free fatty acid production in vitro as the catecholamines but inhibits their effect both in vivo and in vitro. Ergotamine alone reduces the free fatty acid production in vitro but is not able to antagonize the catecholamines in vivo or in vitro, while ergotamine and DCI inhibit the development of hyperglycemia after administration of catecholamines in fish. It is probable that catecholamines trigger their effect on the free fatty acid production in adipose tissue of lower vertebrates through the same mechanism by which they stimulate the lipolysis and glycogenolysis in mammalian adipose tissue.

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