Comparative studies on the effect produced by biologically active agents on the isolated hearts of Helix pomatia L. and Anodonta cygnea L.

S.-Rózsa, Katalin and Pécsi, Tibor (1967) Comparative studies on the effect produced by biologically active agents on the isolated hearts of Helix pomatia L. and Anodonta cygnea L. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 34. pp. 59-72. ISSN 0365-3005

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Abstract

1. Examining the effect of various amino acids and amines on the isolated hearts of Helix and Anodonta it was established that only amines are involved in the production of physiological effects. It was observed that the sensitivity of Helix heart on the agents tested was greater by 2-3 orders. 2. ACh produced on both Helix (10⁻⁹ M) and Anodonta (10⁻⁶ M) hearts negative inotropic and chronotropic effects. 3. Catecholamines (dopamine, noradrenaline, adrenaline) produced stimulation on Helix heart, and inhibition on the heart of Anodonta. 4. 5-HT produced on both objects stimulatory effect at the same threshold concentration (10⁻¹⁰ M) and inhibitory effect was not produceable even on the application of high concentrations. 5. Besides 5-HT other agents as tryptamine, 5-methoxytryptamine and tyramine were also stimulatory factors, the two latter, however, were inhibitory on Helix heart when applied at high concentrations. Tryptophan, glutamine, GABA and histamine produced an increase of amplitude on Helix heart, and were ineffectual on the heart of Anodonta. 6. The effect of ACh was inhibited on both objects by mytolon, and the effect of catecholamines was eliminated or was changed into the opposite effect by this agent. Mytolon does not influence the effect produced by 5-HT and tryptamine. It inhibits the effect of tyramine on the heart of Anodonta, but does not inhibit it on the heart of Helix. 7. BOL ceased the effect produced on the heart of Anodonta by the amines investigated except for ACh. On Helix heart it also did not influence the response produced by ACh, but eliminated the stimulatory effect of 5-HT, tryptamine and tyramine, and decreased to a small extent the effect of catecholamines.

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