The effect of prolonged administration of l-ascorbic and d-gluconic acid on the body-weight, food, water and salt-solution consumption of albino rats

Beznák, Aladár and Beznák, Margit and Gáspár-Rády, Zsuzsanna (1947) The effect of prolonged administration of l-ascorbic and d-gluconic acid on the body-weight, food, water and salt-solution consumption of albino rats. A Magyar Tudományos Akadémia Tihanyi Biológiai Kutatóintézetének évkönyve, 17. pp. 294-308. ISSN 0365-3005

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Abstract

1. A comparison of the alteration in the growth curve caused by administration of hexuronic acids with the curve showing food, saltsolution and water consumption supports the hypothesis that the physiological, and cell biochemical mechanism of growth in mammals changes in the different phases of growth . In the growth curves of the mammals one can differentiate at least five such phases. 2. Neither the Rubner nor the Lusk-Wilson rule is valid for the velocity of growth. The velocity of growth depends chiefly on the direct correlation between velocity and efficiency of growth and the indirect relation between the length of the period of increased food consumption and the efficiency of growth. 3. Among the animal's with large suprarenals. there are more that drink less salt solution than among those with small suprarenals. There is a strong positive correlation between the size of the suprarenal and the efficiency of growth. The variations in consumption of saltsolution and of water bear no relation to one another. 4. The body weight of those rats which receive from their 48th to their 250th day, a daily dose of roughly 200 mg/kg l-ascorbic or d-gluconic acid, is 11.5% greater than that of normal rats. Statistical calculations and the careful weighing of the experimental elements make it likely that the difference is caused by the administration of the acids. Besides stimulating growth, ascorbic and gluconiö acids act in identical ways on 'the consumption of food, salt-solution and water. These effects, therefore, are not due to the anti-scorbutic radical of the ascorbic acid but probably to the acid group present in bath acids.

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