A journey to your self: The vague definition of immune self and its practical implications

Koncz, Balázs and Balogh, Gergő Mihály and Manczinger, Máté (2024) A journey to your self: The vague definition of immune self and its practical implications. Proceedings of the National Academy of Sciences, 121 (23). No.-e2309674121. ISSN 0027-8424

Preview

Text koncz-et-al-2024-a-journey-to-your-self-the-vague-definition-of-immune-self-and-its-practical-implications.pdf - Published Version Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview

Abstract

The identification of immunogenic peptides has become essential in an increasing number of fields in immunology, ranging from tumor immunotherapy to vaccine development. The nature of the adaptive immune response is shaped by the similarity between foreign and self-protein sequences, a concept extensively applied in numerous studies. Can we precisely define the degree of similarity to self? Furthermore, do we accurately define immune self? In the current work, we aim to unravel the conceptual and mechanistic vagueness hindering the assessment of self-similarity. Accordingly, we demonstrate the remarkably low consistency among commonly employed measures and highlight potential avenues for future research.

Actions (login required)

Edit Item