Bipyridil-based chelator for Gd(III) complexation: kinetic, structural and relaxation properties

Bunda, Szilvia and Lihi, Norbert and Szaniszló, Zsófia and Esteban-Gómez, David and Platas-Iglesias, Carlos and Kéri, Mónika and Papp, Gábor Csaba and Kálmán, Ferenc K. (2023) Bipyridil-based chelator for Gd(III) complexation: kinetic, structural and relaxation properties. DALTON TRANSACTIONS, 52 (45). pp. 17030-17040. ISSN 1477-9226 (In Press)

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Abstract

In the last 20 years, the research in the field of MRI (magnetic resonance imaging) contrast agents (CA) has been intensified again related to the appearance of a disease called nephrogenic systemic fibrosis (NSF). NSF was linked to the in vivo dissociation of certain Gd(III)-based compounds applied in MRI as CAs. To prevent the dechelation of the probes after the intravenous injection, the improvement of their in vivo stability is highly desired. The inertness of the Gd(III) chelates can be increased due to the rigidification of the ligand structure. One of the potential ligands is the (2,2',2'',2'''-(([2,2'-bipyridine]-6,6'-diylbis(methylene))bis(azanetriyl))tetraacetic acid) (H4DIPTA) successfully used as fluorescent probe for lanthanides, however, it has never been considered as potential chelator for Gd(III) ion.

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