Nyugat-nílusi vírus fertőzésre adott immunválasz I. rész: Veleszületett és sejthez kötött immunválasz : Irodalmi áttekintés = Immune response to West Nile virus infection Part I.: Innate- and cellular immune response : Literature review

Tolnai, Csenge Hanna and Forgách, Petra and Lőrincz, Márta and Korbacska-Kutasi, Orsolya (2024) Nyugat-nílusi vírus fertőzésre adott immunválasz I. rész: Veleszületett és sejthez kötött immunválasz : Irodalmi áttekintés = Immune response to West Nile virus infection Part I.: Innate- and cellular immune response : Literature review. MAGYAR ÁLLATORVOSOK LAPJA, 146 (10). pp. 625-636. ISSN 0025-004X

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Abstract

A szerzők szakirodalmi adatok alapján bemutatják a nyugat-nílusi vírus által okozott fertőzésre adott immunválasz legfontosabb elemeit. A nyugat-nílusi vírus (Orthoflavivirus nilense – West Nile virus – WNV) az Orthoflavivirus nemzetségbe sorolt szúnyog terjesztette pozitív szimpla szálú RNS-vírus. A kórokozó minden évben jelentős számú idegrendszeri megbetegedést okoz emberekben és lovakban, emiatt napjainkban az egyik legfontosabb, agyvelőgyulladást okozó arbovírusként tartják számon világszerte. A vírus széleskörű előfordulása és az általa jelentett növekvő fenyegetés ellenére is számos kérdés áll fenn a fertőzések klinikai manifesztációjának tekintetében. | West Nile virus (WNV) is a single-stranded positive-sense RNA virus of the Flaviviridae family within the Orthoflavivirus genus. It was first isolated in 1937 in Uganda from a febrile woman and was considered a pathogen with minor significance until the late 1990s. The outbreaks in 1996 in Romania, and 1999 in the United States, respectively, have profoundly changed the perspectives around West Nile virus. Today, the pathogen is endemic on all continents of the world, except for Antarctica, and is considered one of the most important encephalitic arboviruses worldwide. West Nile virus causes a significant number of human and equine neurological cases every year by re-emerging in endemic areas and emerging in new territories. In humans approximately 80% of the infections remain asymptomatic, 20% of the patients develop flu-like symptoms and less than 1% develop neurological signs. In horses, 80-90% of the infections are asymptomatic and 10-20% of the infected animals develop neurological disease, ranging from mild ataxia to recumbency. West Nile virus has become an important threat to the whole world, but the clinical manifestation of the infection is still not understood. In the past 20 years, many research have been made in the area of cellular immune response to WNV infection. It is assumed that the cellular immune response plays an important role in the manifestation of the clinical disease. Exacerbated citotoxic T-cell response, as well as delayed regulatory T-cell response was shown to play a role in the development of severe neurological form, however the regulatory mechanisms behind these pathways are still not clear. The first part of our review provides a summary of the innate- and cellular immune response during and following WNV infections in horses and humans.

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