Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering

Furko, Monika and Horváth, Zsolt Endre and Tolnai, István and Balázsi, Katalin and Balázsi, Csaba (2024) Investigation of Calcium Phosphate-Based Biopolymer Composite Scaffolds for Bone Tissue Engineering. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (24). No. 13716. ISSN 1661-6596

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Abstract

We present a novel method for preparing bioactive and biomineralized calcium phosphate (mCP)-loaded biopolymer composite scaffolds with a porous structure. Two types of polymers were investigated as matrices: one natural, cellulose acetate (CA), and one synthetic, polycaprolactone (PCL). Biomineralized calcium phosphate particles were synthesized via wet chemical precipitation, followed by the addition of organic biominerals, such as magnesium gluconate and zinc gluconate, to enhance the bioactivity of the pure CP phase. We compared the morphological and chemical characteristics of the two types of composites and assessed the effect of biomineralization on the particle structure of pure CP. The precipitated CP primarily consisted of nanocrystalline apatite, and the addition of organic trace elements significantly influenced the morphology by reducing particle size. FE-SEM elemental mapping confirmed the successful incorporation of mCP particles into both CA and PCL polymer matrices. Short-term immersion tests revealed that the decomposition rate of both composites is slow, with moderate and gradual ionic dissolution observed via ICP-OES measurements. The weight loss of the PCL-based composite during immersion was minimal, decreasing by only 0.5%, while the CA-based composite initially exhibited a slight weight increase before gradually decreasing over time.

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