Predictive values of preoperative geriatric nutritional risk index and systemic immune-inflammation index for postoperative complications and 5-year overall survival after curative resection in elderly gastric cancer patients

Liu, Zhijuan and Li, Jingying and Zhu, Yingwei (2025) Predictive values of preoperative geriatric nutritional risk index and systemic immune-inflammation index for postoperative complications and 5-year overall survival after curative resection in elderly gastric cancer patients. PHYSIOLOGY INTERNATIONAL, 112 (4). pp. 445-455. ISSN 2498-602X

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Abstract

Background: Our study evaluated the predictive value of Systemic Immune-Inflammation Index (SII) and the Geriatric Nutritional Risk Index (GNRI), as well as their combined assessment, for predicting the risk of postoperative complication in gastric cancer patients. Methods: We retrospectively collected and analyzed data from elderly gastric cancer patients who underwent gastrectomy from 2013 to 2016. Preoperative measurements, GNRI and SII, were taken for each patient within seven days before surgery. The severity of postoperative complications was evaluated. There were 280 patients who met the criteria, including 187 patients without postoperative complications and 93 patients with postoperative complications. Results: It was observed that patients with postoperative complications had significantly higher preoperative SII indices and significantly lower GNRI indices. In addition, in terms of the severity of complications, as the severity of complications increases, there is a notable increase in the SII index and a marked decrease in the GNRI index. Combined assessment of SII and GNRI significantly improved the sensitivity and specificity compared with either index alone. Conclusions: The concurrent assessment of preoperative SII and GNRI appears to be a valuable tool for predicting long-term prognosis in elderly gastric cancer patients undergoing curative resection.

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