Synthesis and reactivity of self-immolative pDTT-g-pGMA bottlebrush polymer

Uth, Marie and Hansen-Felby, Magnus and Rørbæk Saugbjerg, Jakob and Sommerfeldt, Andreas and Pal, Sunirmal and Henriksen, Martin Lahn and Pedersen, Steen Uttrup and Daasbjerg, Kim (2025) Synthesis and reactivity of self-immolative pDTT-g-pGMA bottlebrush polymer. EXPRESS POLYMER LETTERS, 19 (12). pp. 1216-1225. ISSN 1788-618X

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Abstract

Post-polymerization modification of self-immolative polymers expands the application spectrum of such macromolecular materials. This work demonstrates grafting of poly(glycidyl methacrylate) brushes from a self-immolative poly(DL-dithiothreitol) backbone using activators regenerated by electron transfer–atom transfer radical polymerization (ARGET–ATRP). The polymerization kinetics of the brushes is studied in detail by 1H NMR and size exclusion chromatography, indicating a linear increase in number-average molecular weight. Furthermore, it is demonstrated that the self-immolative properties of the backbone are retained in the bottlebrush polymers by examining the degradation process in solution.

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