Impact of Pelargonium Sidoides on Periodontal Inflammation and Improvement of Oral Health

Skesters, Andrejs and Kustovs, Dmitrijs and Lece, Anna (2022) Impact of Pelargonium Sidoides on Periodontal Inflammation and Improvement of Oral Health. In: Aegyptus et Pannonia VIII. : Acta Symposii anno 2021. Magyar-Egyiptomi Baráti Társaság, Ókori Egyiptomi Bizottság, Budapest, pp. 143-155. ISBN 978-615-6571-02-1

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Abstract

The current study inspects the antioxidant capacity of Pelargonium sidoides DC. crudum root extract (PSRE) and proanthocyanidins isolated f rom Pelargonium sidoides root extract (PACN) for periodontal disease. A total of 77 subjects with periodontitis were enrolled in this study. Oxidative damage to lipids (MDA Adduct, enzymatic antioxidant Cu, Zn-Superoxide Dismutase (Cu, Zn- SOD) activity and Total Antioxidant Status (TAS) were detected in saliva before and after treatment with PSRE or PACN gum chips in different formulations. The initial antioxidant status of periodontal patients’ saliva is characterized by increased concentration of MDA Adduct, TAS and Cu, Zn-SOD. After 3 months of treatment MDA Adduct level decreased using only Ferentis PSRE and PACN gum chips, Cu, Zn-SOD activity decreased in all formulation groups, while TAS remained unchanged. In conclusion, Ferentis PSRE, and PACN gum chips possess antioxidant properties and are suggested as additional support for treatment of the periodontal disease.

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