Use of Bee Bread and Drone Larvae Homogenate in the Treatment of Chronic Bacterial Prostatitis: Results of an Early-Phase Clinical Study

Knizhenko, Valentyna and Iolkin, Viktor (2026) Use of Bee Bread and Drone Larvae Homogenate in the Treatment of Chronic Bacterial Prostatitis: Results of an Early-Phase Clinical Study. APIS, 3 (1). pp. 16-22. ISSN 3058-0382

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Abstract

The development of apitherapy began many centuries ago. However, currently, it is still not a widespread method for the treatment of various diseases. To strengthen the evidence base for apitherapy, a series of clinical studies of bee products was organized.In 2021, at the Kharkiv National Medical University (Ukraine), at the clinical sites of the Department of Urology, Nephrology and Andrology, an early-phase clinical study was conducted on the use of bee products in the complex treatment of chronic bacterial prostatitis.The study included 60 patients with chronic prostatitis who had previously used standard treatment methods. In the complex treatment of these patients, the following combination of bee products was used: 1) lyophilized drone larvae homogenate, 2) suppositories with drone homogenate, 3) bee bread (perga). An important objective of the study was to investigate the tolerability and safety of these bee products, as well as to assess the potential for further in-depth research on this topic.As a result of the complex treatment, high and moderate effectiveness was achieved for 93.3% of patients, and low - only for 6.7%. A significant improvement in clinical and laboratory parameters was achieved: 1) pain on palpation disappeared, 2) the size of the prostate gland decreased and the heterogeneity of its structure disappeared, 3) the number of leukocytes decreased, 4) the number of erythrocytes decreased, 5) testosterone levels increased, etc.It is important to note that this study was conducted as an early-phase study using a «patient-as-own-control» methodology, which was reflected in both the study design and the interpretation of its results.An early-phase clinical study of the use of homogenate of drone larvae and bee bread for patients with chronic bacterial prostatitis showed their high effectiveness and tolerability. Therefore, these natural and safe products are very promising for further research and practical application for the prevention and treatment of various diseases.

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