Autoantibodies testing in autoimmunity: Diagnostic, prognostic and classification value

Sciascia, Savino and Bizzaro, Nicola and Meroni, Pier Luigi and Dimitrios, Bogdanos and Borghi, Maria Orietta and Bossuyt, Xavier and Grossi, Claudia and Tornai, Dávid and Papp, Maria and Shoenfeld, Yehuda and Ielo, Daniele and Fritzler, Marvin J. (2023) Autoantibodies testing in autoimmunity: Diagnostic, prognostic and classification value. Autoimmunity Reviews, 22 (7). No. 103356. ISSN 15689972

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Abstract

Diagnosis of autoimmune diseases is in most cases challenging for clinicians as there is not a single specific laboratory or histological marker to diagnose or exclude the presence of the conditions. This review focused on the current knowledge of the role of autoantibodies’ testing in various diseases, such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, undifferentiated connective tissues disease, primary biliary cholangitis and primary sclerosing cholangitis. Similarly, the prognostic and diagnostic values of autoantibodies testing in patients with interstitial lung disease have been reviewed. In-depth research on the molecular action of these autoantibodies on immune regulation and diseases pathogenesis has been explored beyond their correlation with disease phenotypes, highlighting the impact of autoantibodies targeting on disease outcomes and etiopathogenesis.

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