Functionalized Cyclic Beta‐Amino Acid Derivatives With Antiviral Potential

Nonn, Melinda and Denel‐Bobrowska, Marta and Volk, Balázs and Olejniczak, Agnieszka B. and Kiss, Loránd (2026) Functionalized Cyclic Beta‐Amino Acid Derivatives With Antiviral Potential. CHEMMEDCHEM, 21 (6). No. e202500862. ISSN 1860-7179

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Abstract

Selected highly functionalized cyclic beta (β)‐amino acid derivatives have been synthesized according to modified and improved literature synthetic protocols and subjected to various antiviral studies. The model compounds were regio‐ and stereoisomers of azido‐functionalized β‐amino esters, orthogonally protected diamino esters, an oxirane‐fused cyclic β‐amino ester, 1,2,3‐triazole‐substituted β‐amino esters, mono‐ and difluorinated cyclic β‐amino esters, mono and dihydroxylated cyclic β‐amino esters, dihydroxylated lactams, and β‐amino esters with piperidine and azepane skeletons. Formed compounds have been investigated and their anti‐HCMV (Human cytomegalovirus), anti‐HRV8 (Human rhinovirus 8), and anti‐HSV‐1 (Human herpesvirus 1) activities were tested (CC50 and IC50 determinations) during screening studies.

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