Identifying prior evidence for new trials (REVEAL): guidance for clinical researchers

Griebler, Ursula and Ledinger, Dominic and Klerings, Irma and Schandelmaier, Stefan and Dobrescu, Andreea and Deschodt, Mieke and McLennan, Stuart and Hemkens, Lars G and Nussbaumer-Streit, Barbara and Briel, Matthias (2026) Identifying prior evidence for new trials (REVEAL): guidance for clinical researchers. BMJ (Clinical research ed.), 392. No. e083718. ISSN 1756-1833

Text Griebler_Schandelmaier_BMJ_2026.pdf - Published Version Restricted to Repository staff only Download (290kB) | Request a copy

Abstract

Conducting a systematic literature review before initiating a new clinical trial can prevent research waste and provide critical justification and valuable insights for designing the trial. Clinical researchers, however, typically lack the resources and experience to conduct systematic reviews. This paper introduces the REVEAL (prior evidence for new trials) guidance—a rigorously developed, user-friendly, step-by-step guide for clinical researchers to rapidly, efficiently, and systematically review the literature when planning a trial. REVEAL consists of a detailed guidance document to navigate the process, a structured report form to document the search and findings, and a worked example for practical orientation.

Actions (login required)

View Item